How Do Drugs Interact With Receptors Biology Essay

How Do Drugs Interact With Receptors Biology Essay Illustrate with named drug examples. Receptors are highly important in cell function as they allow communication between a cell and its neighbours and controls the way a cell functions with stimuli or depression, usually from the central nervous system via the brain and spinal cord (Patrick, 2005). The nerves that communicate with their respective cells do not connect directly to their target cells, and there has to be some way of carrying their message across a gap of only 100 Ã…, and this is achieved by the release of chemical messengers from the nerve cell to interact with receptors in the target cell membrane (Patrick, 2005). These receptors are protein molecules, usually embedded in the cell membrane, with a certain area of this protein on the outside of the cell which is able to bind this chemical messenger due to the proteins structure. This binding of the chemical messenger leads to the activation of the receptor which leads to the desired effect which can occur via a numb er of methods (Katzung, 2001). When this process goes wrong, for example of too much or not enough messengers are released, then disease states can occur, with Parkinsons disease, depression and psychosis being among many diseases thought to be resulting from this sort of pathophysiology (Patrick, 2005). When this occurs, drugs, which may be defined as any substance that brings about a change in biological function through its chemical actions (Katzung, 2001), can be used to have an effect on the desired receptors to increase or decrease their activity, and hopefully restore the balance as close to the physiological normal as possible. In this essay, I shall first discuss how drugs can have their effect on receptors and will then go on to discuss how these drugs work on different types of receptors to treat disease. There are many, many different receptors in the body with different shapes, sizes, regulating factors and functions. These can be classified into five main classes: (i) ligand gated ion channels, (ii) intracellular receptors for lipid soluble agents, (iii) ligand regulated transmembrane enzymes, (iv) cytokine receptors, and (v) G proteins and second messengers (Patrick, 2005). Throughout the essay, I will try to explain how drugs interact with receptors and how this can affect their function. I will also try and use a balanced coverage of the above receptor classes as examples when describing how drugs can affect a receptors function. Firstly, a drug may be used to mimic the action of a natural chemical messenger to activate the receptor and cause an increase of activity at that cell, for example, initiating muscle movement or secretion of a hormone (Patrick, 2005). These types of drugs are called agonists, but their function at a receptor depends on a number of factors that need to be considered when designing new drugs. One requirement is that the drug has to have the correct binding groups, so that the required number of interactions, for example, ionic bonding, hydrogen bonding, van der Waals interactions etc.; can be made between the drug and the receptor, and that these interactions are strong enough to stimulate the receptor, but not too strong so that the drug does not leave the receptor after binding (Katzung, 2001). The drug must also have the correct size and shape to fit into the receptor binding site and allow these interactions to occur. If the drug is too small, the drug will not be able to sufficie ntly form the required interactions with the receptor, and if too big, the drug will not be able to fit into the binding site at all. This has become a lot easier since the protein structures of many receptors, and their binding sites, have been identified via genetic engineering, computer based molecular modeling and X ray crystallography, allowing for the design of specific drugs to fit these binding sites (Patrick, 2005). In terms of how the chemical messengers and drugs have their effect on the receptor to activate it, it is thought that the binding interactions of the messenger molecule cause the receptor to change shape. As an example, if a receptor had three binding sites, when the agonist reaches the receptor, it may only interact with two of the three required interactions. In order for the third interaction to take place, the protein must undergo a conformational change, and with this change, the receptor will become activated and cause a change in the cells activity (Katz ung, 2001). This is a very simplified view and in reality, the conformational changes needed to open a channel such as an ion channel are complex and often, the lock gate is not in close proximity to the receptor binding site, but the same ideas are common to both. A very common prescribed agonist is Salbutamol, a selective ÃŽ ²-2 adrenergic receptor agonist, in the treatment of asthma (Waldeck, 2002). This is a G protein coupled receptor which is expressed mainly in the lungs in the alveolar walls. When this receptor is activated, levels of intracellular cyclic adenosine monophosphate (cAMP) via G-protein activation of adenyl cyclase. The increase in cAMP in the cells influences cAMP dependant protein kinases which contribute to regulation of muscle tone and reduce free calcium ions on the cell by stopping their influx from outside the cell and also their release from intracellular stores (Kroeze, 2003). This then results in relaxation of the central and peripheral airway smooth muscle and therefore bronchodilation (Sears, 2005). Benzodiazepines can be used as anticonvulsants for treatment of epileptic seizures and work by acting as agonists of the GABAA receptor in the central nervous system. These work by binding to a specific benzodiazepine binding site at the interface of the ÃŽ ± and ÃŽ ³ subunits which is present on a subset of GABAA receptors (Treiman, 2001). When a benzodiazepine binds to this site, it increases the affinity of the receptor protein to bind GABA, and therefore increases the chance that the channel will open. With the channel more likely to be open, this allows the flow of chloride ions through the channel and therefore hyperpolarizes the membrane and makes the associated neuron less likely to potentiate an action potential, hence the drugs sedative properties (Treiman, 2001). Agonists are a good therapeutics agent for when there is not enough chemical messenger in a system, but what if there is too much being produced? In this situation, an antagonist is used. An antagonist is a drug that can bind to a receptor binding site but does not produce a functional conformational change like an agonist, or if it does change the shape of the receptor protein, it does so in a way in which the desired effect on the cell does not occur (Patrick, 2005). These are called competitive antagonists as they compete with the natural chemical messenger for the receptor binding site and therefore block the action of the messenger, preventing it from having its effect. Competitive agonists are usually designed to bind to the binding site more strongly, so enhancing its anagonistic effects (Patrick, 2005). Antagonists can also work on the receptors but not actually at the binding site. These are termed allosteric antagonists with the drug binding to a different part of the recep tor and the interactions involved may then distort the shape of the receptor in such a way that the natural chemical transmitter cannot bind as the binding site will no longer be compatible. This is an example of non-competitive antagonism as the drug is not competing with the natural chemical messenger for the same binding site (Katzung, 2001). An example of an ion channel antagonist is Amlodipine, which has its effect on voltage gated L-type (slowly inactivating) calcium channels (Abernethy, 1999). This drug is used for a variety of cardiovascular diseases, for example, hypertension and angina pectoris (Abernethy, 1999). With the calcium channels blocked, there is less influx of calcium into the cell, and in smooth muscle cells, this decrease in the intracellular messenger leads to a reduction in muscle contraction. This means that vasodilation takes place and leads to a decrease in blood pressure (Abernethy, 1999). Sometimes, a drug is discovered that cannot be classed as a pure agonist or a pure antagonist, its action involves it having some effect on a receptor to produce its activation, but not as much as would be seen with an agonist. These are termed partial agonists. There are many theories into how these work because it does seem strange that an agonist can only work partially. One such explanation is that when the partial agonist binds to the binding site, it does form the required interactions to produce a conformational change, but this change is not exactly the same as a pure agonist, and so may only activate the channel partially, for example, by only partly opening an ion channel (Patrick, 2005). Another theory involves the partial agonist being able to bind to the receptor in more than one place, so one method of binding would produce an agonist effect and the other an antagonist effect. This balance between the two would result in only a proportion of the receptors being activate d, hence, the partial antagonistic effect (Katzung, 2001). An example of a partial agonist is clozapine which is classified as an atypical antipsychotic and can be used for its anti-depressive and anti-anxiolytic effects in some patients. Along with effecting dopamine receptors, it also binds to serotonergic receptors, particularly the 5-HT1A receptor, to which it has its partial agonist effect (Meltzer, 1989). There is another way drugs can interact with receptors and this is in the form of an inverse agonist. These work on the principle that some receptors have constitutive activity, for example the GABA receptors, in which they are active at all times, regardless of signals they are receiving, so can be active even without the presence of a natural chemical messenger or an agonist (Patrick, 2005). This can even be true when an antagonist is present as the antagonist has the same binding affinity to both the active and inactive receptors, so there is no change in biological activity because the active receptor remains active. An inverse agonist has the effect of binding to the receptors and stabilising them in the inactive state, so will reduce the number of active receptors that are functioning, so will almost prevent any receptors from being active as it even stops the constitutive activity, so has a negative efficacy (Patrick, 2005). Figure 1 represents a diagrammatical representation of this (Lambert, 2004). Cimetidine, a H2 receptor inverse agonist, is used for the treatment of dyspepsia and peptic ulcers (Wallmark, 1983). It works by blocking the binding of histamine to the receptor on the parietal cells which reduces the amount of acid that is secreted by these cells into the stomach (Wallmark, 1983). The parietal cells secrete more acid when stimulated by histamine release after a meal, but also have a constitutive activity, which the inverse agonist also suppresses (Wallmark, 1983). Fig. 1 Graphical representation of the negative effect that inverse agonists have on receptors when compared to an antagonist and an agonist (Lambert, 2004). In conclusion, there is many ways in which drugs can act on receptors to modify their effect and this can be utilised for treating disease when a system goes out of balance. As mentioned previously, huge advancements have been made since more is now known regarding the structure of receptors and their binding sites. In the future, with more knowledge acquired in this field, further drugs can be manufactured which can be much more specific to their respective receptor and so can produce specific desired effects. This is of particular importance in conditions affecting the brain as disorders such as depression, schizophrenia and Parkinsons disease are associated with an imbalance in neurotransmitters and improvements in the drugs available to us to treat such conditions will benefit millions of people all around the world.

Marketing :: essays research papers

Rockford Register Star Sunday, March 27, 2005 Business Section, Page 4C Hyundai, Kia shift gears to pass competition   Ã‚  Ã‚  Ã‚  Ã‚  In this article, the Rockford Register Star discusses the most recent marketing changes in the Korean owned auto companies of Kia and Hyundai. The Korean cars are the second fastest growing car brand in America, trailing behind BMW. Kia and Hyundai had only two car models in 1999; and as of 2005 there are nine. They have announced their â€Å"24/7† plan that they say they will introduce seven new cars in the next twenty-four months. They plan to introduce and promote a new line of cars in the United States that appeal to the budget of everyone. They have lower end cheaper sedan cars and higher end luxury style sedans that may be a little more expensive that compare with that of the Honda Accord or Toyota Camry. The new line also included a sporty vehicle that will appeal to that of a gear-head teen who desires more power which ensuring a focus on safety with six air bags and the normal equipment that is standard on modern cars. (ABS, Electronic Stability Co ntrol, CD/Stereo, etc). Kia and Hyundai promises that their cars are reliable and worth the dollar. As said in â€Å"Consumer Reports Magazine†, The Hyundia Sonata was named most reliable car in the 2004 model year. The article states that with the introduction of these new cars and new quality standards, Kia and Hyundai will new competition for Japan’s Big 3 auto companies. The article stated that names Kia and Hyundai are now auto names respected and associated with quality and a standard of safety.   Ã‚  Ã‚  Ã‚  Ã‚  This article deals with our business class in a sense that Kia and Hyundai are creating cars and marketing them to appeal to all types of people in all ranges of income. These cars will have a reasonable price and yet have the quality of the industry standards. They are marketing these cars with a status of quality and reliability that is now associated with the Korean based auto companies to compete with other auto companies; both domestic and imported vehicles while at the same time offering a variety of styles to appease the desires of a vast group of ages.   Ã‚  Ã‚  Ã‚  Ã‚  I’ve learned that companies, if they want to be successful, need to market a product to the right people at the rice price. Also, companies need to market a product with a variety of styles to catch the eye of different shoppers.

Cause And Prevention Of Cancer Health Essay

Cancer is a word used for diseases in which unusual cells split without control and are able to assail other tissues. It ‘s cells can make other parts of the organic structure through the blood and lymph system. It is non merely one disease but many diseases. There are over 100 different types of malignant neoplastic disease. To recognize malignant neoplastic disease, it ‘s utile to cognize what happens when normal cells become malignant neoplastic disease cells. The organic structure is made up of many types of cells. These cells grow and split in a controlled manner to make more cells as they are necessary to maintain the organic structure strong. When cells become old or hurt, they pass off and are replaced with new cells. Despite that, sometimes this organized method goes wrong. The familial stuff ( DNA ) of a cell can go injury or misused, bring forthing mutants that concern normal cell growing and division. Equally shortly as this happens, cells do non decease as th ey should and new cells signifier when the organic structure does non necessitate them. Image coroneted Loss of Normal Growth Control. The image shows normal cell division and normal cell self-destruction or programmed cell death of a damaged cell. It besides shows malignant neoplastic disease cell division, through several mutant phases, stoping in uncontrolled growing.Types of CancerThe followers are the most normally known types of malignant neoplastic diseases. Bladder Cancer: It is a wild unusual growing and addition of cells in the urinary vesica which have busted free from the usual mechanisms of the organic structure. It has the capableness to multiply to other organic structure parts every bit good as to the lungs, castanetss, and liver. Breast Cancer: It is a malignant neoplastic disease that starts in the tissues of the chest. Endometrial malignant neoplastic disease: It develops when the cells that make up the interior liner of the uterus become unnatural and grows uncontrollably and it is the 4th most general type of malignant neoplastic disease between adult females and the most general gynecologic malignant neoplastic disease. Kidney malignant neoplastic disease: It forms in tissues of the kidneys. It includes nephritic cell carcinoma and nephritic pelvic girdle carcinoma. It besides includes Wilms tumour, which is a type of kidney malignant neoplastic disease that on a regular basis develops in kids under the age of 5. Leukemia: It starts in the tissue that forms blood. Lung malignant neoplastic disease: It is a consequence from a defect in the cell. Normally, the organic structure maintains a method of cheques and balances on cell growing so that cells split to make new cells merely when new cells are needed. Melanoma: It is a type of skin malignant neoplastic disease. It begins in cells in the tegument called melanocytes. Non-Hodgkin lymphoma: It starts in cells called lymph cells, which are portion of the organic structure ‘s immune system. Lymphocytes are in the lymph nodes and other lymphoid tissues. Pancreatic malignant neoplastic disease: It begins in the tissues of your pancreas which is an organ in your venters that lies directly to the rear of the lower portion of your belly. The pancreas secretes enzymes that aid digestion and endocrines that aid control the metamorphosis of sugars. Prostate malignant neoplastic disease: It is a barbarous tumour that consists of cells from the prostate secretory organ. Normally, the tumour grows easy and remains restricted to the secretory organ for many old ages. Throughout this clip, the tumour produces little or no symptoms.The Causes of CancerThe followers are the most normally known causes of malignant neoplastic disease. Tobacco: Harmonizing to the Nationwide Cancer Institute, smoking causes 30 % of all malignant neoplastic disease deceases in the U.S. and is to fault for 87 % of instances of lung malignant neoplastic disease. Not merely does it hold an consequence on the lungs, it can besides do kidney, pancreatic, cervical, and tummy malignant neoplastic diseases and acute myeloid leukaemia. Geneticss: It can play a big undertaking in malignant neoplastic disease addition. If you have a household record of malignant neoplastic disease, for illustration chest malignant neoplastic disease, taking extra safety steps is important. When malignant neoplastic disease is familial, a mutated Deoxyribonucleic acid can be passed down. Familial trials are offered for many familial malignant neoplastic diseases. Keep in head that if you have a household record of malignant neoplastic disease, it does non intend you will hold it. You merely have a greater opportunity of making it. Environmental Factors: The milieus you are in can do malignant neoplastic disease. Surveies have revealed that people who are exposed to high measure of benzine are at menace for malignant neoplastic disease. It is a chemical originated by gasolene, smoke, and pollution. Sun Exposure: Skin malignant neoplastic disease is caused by contact with the UV beams of the Sun. Sunburn or a sunburn is genuinely the consequence of cell harm caused by the Sun.The Prevention of CancerThe followers are the most known ways of forestalling malignant neoplastic diseaseAvoid Smoking and Exposure to SmokeSmoke is the most of import malignant neoplastic disease menace that we can cut down. It is to fault non merely for lung malignant neoplastic disease, but many other types of malignant neoplastic disease. One of the finest ways to avoid malignant neoplastic disease is to halt smoke or ne'er get down. The blink of an eye you quit your organic structure reaps the benefits of being tobacco-free.Practice Sun Safety and Recognize When Skin Changes OccurSkin malignant neoplastic disease is the most ordinary type of malignant neoplastic disease between work forces and adult females, and it accounts for about half of all malignant neoplastic disease diagnosing. The first measu re in forestalling skin malignant neoplastic disease is to remain off from UV beam contact. We can make this by have oning sunblock, avoiding noontime Sun, have oning defensive apparels when exterior, and by remaining off from tanning beds. Eat Your Fruits and Vegetables A well-balanced diet is helpful in many ways. A diet loaded with fruits and veggies to a great extent reduces the opportunity of developing malignant neoplastic disease and many other fortunes. Fruits and veggies hold antioxidants, which help repair our injury cells. Green, orange and xanthous fruits and veggies are the greatest opportunity to assist avoid malignant neoplastic disease. Surveies besides explain that dark fruits, like blueberries and grapes, may besides hold anti-cancer belongingss. Limit Red Meat and Animal Fat Several surveies explain that a diet high in carnal fat increases the danger of many types of malignant neoplastic disease, chiefly colon malignant neoplastic disease. Red meat holds much more fat than biddy and fish, so dropping the measure of ruddy meat in your diet may help to halt malignant neoplastic disease. A diet high in fat besides is chief cause of fleshiness, which is a menace for many types of malignant neoplastic disease. Restrict Your Alcohol Intake Devouring excessively much sums of intoxicant frequently increases the menace for several types of malignant neoplastic disease. Surveies propose that work forces who drink two alcoholic drinks per twenty-four hours and adult females who have one alcoholic imbibe per twenty-four hours well add to the menace for certain types of malignant neoplastic disease.Exercise for Cancer PreventionThe American Cancer Society advises exerting 30 proceedingss a twenty-four hours, at least 5 yearss a hebdomad for malignant neoplastic disease turning away. Exercise does n't hold to bespeak go forthing for the gym to raise weights. There are plentifulness of ways to acquire exercising into your twenty-four hours.Know what you ‘re being exposed to in Your Work EnvironmentChemicals in the topographic point of work may add to the menace of increasing many types of malignant neoplastic disease, plus kidney malignant neoplastic disease and vesica malignant neoplastic disease. Get Screened for Cancer Regularly Cancer testing trials can be helpful non merely for happening malignant neoplastic disease, but besides assisting halt it. Screening trials similar to the colonoscopy and Pap smear can observe unusual cellular alterations before they become cancerous.The Treatments for CancerThe followers are the most common interventions for malignant neoplastic disease Chemotherapy: It is the common term for any remedy refering the usage of chemical agents to forestall malignant neoplastic disease cells from increasing. It can acquire rid of malignant neoplastic disease cells at great distances from the original malignant neoplastic disease. Therefore, it is considered a systemic intervention. More than half of all people diagnosed with malignant neoplastic disease are given chemotherapy. For 1000000s of people, it helps handle their malignant neoplastic disease successfully, leting them to profit from full, originative lives. Radiation Therapy: It uses high-energy radiation to minimise tumours and kill malignant neoplastic disease cells. X raies, gamma beams, and charged atoms are types of radiation used for malignant neoplastic disease remedy. The radiation may be delivered by a device outside the organic structure, or it may come from radioactive affair located in the organic structure near malignant neoplastic disease cells. It uses radioactive substances, for case radioactive I, that pass through in the blood to kill malignant neoplastic disease cells. About half of all malignant neoplastic disease patients are given some type of radiation therapy sometime during the class of their remedy. Cryosurgery: It is the usage of utmost cold formed by liquid N to pulverize unusual tissue. It is used to handle external tumours, for case those on the tegument. For exterior tumours, liquid N is applied straight to the malignant neoplastic disease cells with a cotton swab or spraying device. Cryosurgery is besides used to handle tumours inside the organic structure. For internal tumours, liquid N or Ar gas is spread through an empty device called a call investigation, which is placed in contact with the tumour. The physician uses ultrasound or MRI to direct the call investigation and detect the freeze of the cells, therefore restricting injury to shut by strong tissue. A ball of ice crystals forms around the investigation, stop deading close by cells. Sometimes more than one investigation is used to direct the liquid N to different parts of the tumour. The investigations may be put into the tumour during surgery or through the tegument. After cryosurgery, the frozen tissue melt and is either of course absorbed by the organic structure, or it dissolves and forms an outer bed.

The Hunger Games By Suzanne Collins - 1419 Words

Contrary to the belief that feelings like fear and sorrow dominate the emotional atmosphere within a dystopian state, there exists an absence of feeling which competes for dominance. Suzanne Collins’ demonstrates this competing apathetic mood in her novel, The Hunger Games, through the citizens of the divided dystopia of Panem. This essay will analyze the origins and influence of apathy on a people and an individual, in both a political and personal sense. Collins’ main argument, that citizens’ facing governmental oppression can either become compliant with apathy, or, instead, utilize apathy in creating a false appearance to increase their chances of survival in a sadistic society, is conveyed with contextual motivation for the protagonist’s actions, exploration into false appearances, and through a lack of material resources. Intentionally failing to provide material resources is an effective tool used by oppressive governments to smother a person’s hope, joys, and ambitions. A consequence of being forced to get by on conditions which breach the point of starvation is that those feelings mentioned gradually fade away. Consequently, this fading signals apathy’s emergence within a populace. It leaves a people who feel no emotions because doing so can cause weakness in a society dominated by hardships. Collins’ introduces her audience to the apathetic mood of those in District 12 through the coal miners’ unkempt appearances. Describing them as no longer caring to clean â€Å"theShow MoreRelatedThe Hunger Games By Suzanne Collins3246 Words   |  13 PagesStudy Unit The Hunger Games by Suzanne Collins and Steven Galloway’s The Cellist of Sarajevo demonstrates the way in which people are affected by war, and a brutal dictatorship. The authors illustrates the main purpose for writing their novel through the use of imagery, characterization, foreshadowing, flashback, similes, and symbolism. Suzanne Collins and Steven Galloway use imagery and characterization to vividly describe the effects and outcomes of war and dictatorship. Suzanne Collins portrays,Read MoreThe Hunger Games By Suzanne Collins1352 Words   |  6 PagesThe movie or the book the Hunger Games came out with a bang when it first hit theaters or the shelves of the bookstores. It was dubbed as one of the best films or books to read, interestingly enough it was a remake of the stories or myths most people heard when they were younger, but modernized and turned into a collage of all the best roman and Greek stories. Suzanne Collins brilliantly combined the Greek and Roman influences to make the movie/book unforgettable. By using stories from the romansRead MoreThe Hunger Games By Suzanne Collin899 Words   |  4 Pages Suzanne Collin’s â€Å"Hunger Games† seems to be about a dystopian society struggle to become a utopia. However, when the readers read further in to the book or watches the movie one can see that is about all the characters that make use human. As human, we feel the need to build an ethical framework based on our needs for authority rather than tradition. The Capitol in the Hunger Games exploits human needs to keep authority in place. After rising seas and poverty consumed much of the land, the CapitolRead MoreThe Hunger Games By Suzanne Collins854 Words   |  4 PagesIn a place where poverty is prevalent and a country is ruled by a tyrannical dictator is it possible for an individual to trust others when their own life is always at stake? In the book The Hunger Games by Suzanne Collins, the main character Katniss Everdeen is a survivor. In the novel she is put into an arena to compete against twenty-three other tributes to the death. This is not the only time during which she has to fend for herself; at home she had to care for her family and keep them aliveRead MoreThe Hunger Games by Suzanne Collins710 Words   |  3 Pages‘’The hunger games’’ is a novel written by Suzanne Collins, published in 2008. The genre of the book is thriller/survival, and is written over 27 chapters with 454 pages. In this analysis, I will tell you about how the main character Katniss changes through the novel, and tell you a little about the central characters that plays an important role for her. ‘’The Hunger Games’’, is set in the future in the country Panem, and is about the sixteen-year-old girl, Katniss Everdeen. Panem is divided intoRead MoreThe Hunger Games By Suzanne Collins986 Words   |  4 PagesThe Hunger Games by Suzanne Collins is about a sixteen year old girl named Katniss and how she needs to fight for her life. The Hunger Games takes place in an arena in the Capitol of Panem. There are 24 tributes, two from each District. The games were created to punish the Twelve Districts for trying to create an uprising against the Capitol. Suzanne Collins book could be compared to the United States and how people obsess with the way they look, discrimination is still occurring, and how the governmentRead MoreThe Hunger Games By Suzanne Collins3514 Words   |  15 PagesThe Hunger Games is a science fiction, dystopian post-apocalyptic series that takes place in a futuristic North American nation called Panem. The film series is based on the nov el series of the same title written by Suzanne Collins. Many who watch the films view them as an action-packed adventure series, but The Hunger Games, like many other dystopian films, feature social and political subjects that relate back to past and present culture. Dystopian films like the Hunger Games provide messages,Read MoreThe Hunger Games By Suzanne Collins1487 Words   |  6 PagesMy first text is The Hunger Games which is written by Suzanne Collins and it was written in September 14 2008; was set in the future, around the year 2087. My second text which is 1984, which is written by George Orwell and was written on Wednesday June 8 1949 and it was set in 1948. There are many themes in the book hunger games such as ‘the inequality between rich and poor’, ‘suffering as environment’ and ‘the importance of appearances’. In 1984 there is also many themes portrayed such as ‘theRead MoreThe Hunger Games By Suzanne Collins2436 Words   |  10 PagesThe Hunger Games is a science fiction and adventure film, based on the novel written by Suzanne Collins, which explores concepts of Marxism and numerous aspects of its principles through the dystopian world of Panem. The Hunger Games follows Marxist theories on bourgeoisie and proletariat class structure as well as capitalist production and the distribution of good. Thelma and Louise, a 1991 film directed by Ridley Scott, is often referred to by critics as â€Å"the ultimate feminist film†. This filmRead MoreThe Hunger Games By Suzanne Collins1237 Words   |  5 PagesImagine you and your family suddenly have to move from Salt Lake City UT all the way to†¦ Antarctica! Of course it isn t realistic for someone to live in Antarctica, but then again, The Hunger Games isn t that much different. Picture you are moving to Antarctica, away from people, friends, extended family, warmth, life, entertainment, happiness! You finally arrive to your isolated, barren pl anes of snow and ice for a home and realize, BAM! Where is religion in your life? Where will you go for church